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What is Paxil CR?

Paxil CR (paroxetine) is a medicine used for the treatment of a premenstrual dysphoric disorder, obsessive-compulsive disorder, anxiety disorders, depression and post-traumatic stress disorder. This drug is classified as a selective serotonin reuptake inhibitor and works for the patient by restoring the balance of chemicals. Their imbalance may lead to the problem and symptoms described. This drug should never be taken together with monoamine oxidase inhibitors, as well as pimozide, thioridazine or linezolid to avoid dangerous interactions, which is something you need to know before you buy Paxil CR online. In fact, more and more people use online pharmacies. Most often, such patients choose to buy the drug at a dose of 12.5 mg, because this is the most commonly prescribed dose that works well for the patient. If you need to buy this antidepressant but do not think you will be able to afford shopping for it at the local pharmacy, you can buy it online. Online pharmacies give you round the clock possibility to buy medication in the most convenient way and taking advantage of the numerous payment options offered, which makes it quite enjoyable and always safe.

Dosage and administration

Paxil should be taken once a day, without chewing, better in the morning, while eating. Depending on the clinical condition of the patient, the dosage can be changed after 2-3 weeks.

The recommended daily dose for treating depression is 20 mg. The therapeutic effect usually develops gradually. To achieve a therapeutic effect, the daily dose may be increased by 10 mg with an interval of one week. The maximum dose is 50 mg per day.


Overdose symptoms: tremor, mydriasis, vomiting, irritability, dry mouth, nystagmus (oscillatory eye movements), agitated state, sweating, sinus tachycardia, drowsiness, coma, convulsions, increased arterial pressure, bradycardia, nodal rhythm. In severe overdose, serotonin syndrome and rhabdomyolysis may occur.

Treatment of overdose: gastric lavage, taking sorbents, symptomatic therapy.

Side effects

  • Neurological disorders: drowsiness, tremor, weakness, fatigue, paresthesias, irritability, insomnia, headache, dizziness, extrapyramidal disorders, somnambulism, epileptiform seizures, orofacial dystonia, increased intracranial pressure;
  • Cardiovascular disorders: fainting, tachycardia, ECG changes, blood pressure instability;
  • Perception disorders: visual impairment, attack of acute glaucoma, mydriasis;
  • Urinary and sexual disorders: impaired ejaculation, difficulty urinating, change in libido, edema, impaired consciousness;
  • Digestive disorders: decreased appetite, nausea, constipation/diarrhea, increased liver function tests, impaired liver function;
  • Vegetative disorders: excessive sweating, dry mouth;
  • Dermatological reactions: redness, subcutaneous hemorrhage, bronchospasm, urticaria, angioedema, pruritus;
  • Others: myopathies, myalgia, hyperglycemia, hyperprolactinemia, fever, galactorrhea, hypoglycemia, the development of a flu-like state, thrombocytopenia, increase/decrease in body weight, bleeding.

Abrupt withdrawal of the medication can cause sensitivity disorders, dizziness, feeling of fear, agitation, sleep disturbance, tremor, sweating, confusion, nausea, therefore, discontinuation of therapy should be performed gradually.

Safety precautions

Before you decide to use Paxil, talking to your doctor is always a good idea. Talking to your doctor will allow figuring out whether such health aspects as narrow-angle glaucoma, manic depression, bleeding disorder, a history of drug abuse or suicidal thoughts, seizures, kidney disease, liver disease, epilepsy or blood clotting disorder are likely to interact with your treatment unless timely reported. Your doctor will also need to know if you are taking any drugs that can add sleepiness: anxiety medicine, narcotic pain medicine, sleeping pills, cold or allergy medicine, sedatives, muscle relaxers or medicine for seizures. Other drugs you need to report to avoid interactions with paroxetine are zolmitriptan, psychiatric disorder medicine, linezolid, naratriptan, frovatriptan, theophylline, cimetidine, rizatriptan, heart medications, tryptophan, fosamprenavir, tamoxifen, fentanyl, almotriptan, tramadol, sumatriptan, ritonavir, St. John’s wort and certain blood thinners.

Important recommendations

To benefit from the treatment, you will have to know exactly how this drug should be taken. You should also know that you should not take this medicine during pregnancy. However, your doctor may still recommend you to buy Paxil CR 12.5 mg and carry on with the treatment, since stopping the treatment suddenly can cause even more serious health consequences for the child due to a relapse of depression. You should take tablets with some food or without, in the same way every time you do. Don’t chew or crush the tablet: CR stands for controlled released, which means the tablet must be allowed to dissolve slowly in your stomach. It’s best if your routine is the same and you follow all the directions of your doctor when it comes to your dose being adjusted to get the most efficiency. You may not notice the benefits of the treatment until after 4 weeks of the treatment, during which time you are supposed to keep taking the drug regularly.